I’ve coated hair regeneration analysis by Yokohama National University (Japan) primarily based scientist Dr. Junji Fukuda just a few occasions up to now. His workforce’s most essential work pertains to hair multiplication through the manufacturing of hair follicle germs.
However, Dr. Fukuda achieved international notoriety in 2018 as a result of French Fries chemical associated hair loss “cure”. In latest years, the Yokohama Team has printed quite a few papers. Moreover, they plan to start hair multiplication trials in people in 2023. I replace this put up usually as a result of significance I connect to Dr. Fukuda’s work. Make certain to additionally examine Fukuda Lab for the most recent information.
October 21, 2022
The un-finalized paper that I discussed in my prior June replace was simply launched right this moment. Lots of media protection.
In one more breakthrough, the Yokahama University workforce led by Junji Fukuda and Tatsuto Kageyama have managed to develop mature mice hair follicles in cultures. Actual paper here and was printed right this moment. The information is already being coated broadly in quite a lot of publications, together with US News and Yahoo.
According to Newscientist:
Mature hair follicles have been grown in a laboratory for the primary time, in a transfer that might sooner or later deal with hair loss.
The hair follicles grew for as much as one month, reaching 3 millimetres size. According to Dr. Fukuda, that is in all probability resulting from the truth that the mice hair cycle is about one month. Quote from the great physician:
Our subsequent step is to make use of cells from human origin, and apply for drug improvement and regenerative drugs.
Also be aware that the identical workforce launched a new paper on October 1 titled: “Impacts of manipulating cell sorting on in vitro hair follicle regeneration.”
June 25, 2022
The updates from Dr. Fukuda and his workforce at Yokohama National University (YNU) hold coming and I’m excited. Thanks to “Ben” for the hyperlinks to the 2 newest papers. Also ensure that to see Dr. Fukuda’s patents page.
Junji Fukuda and TrichoSeeds
- On June 16, the Fukuda Lab published a new paper titled: “Bioprinting of hair follicle germs for hair regenerative medicine.” This examine outlines an strategy for the scalable and automatic preparation of extremely hair-inductive grafts utilizing a bioprinter (picture above). The examine hyperlink additionally contains two attention-grabbing movies on the backside.
However, maybe of most curiosity to me, they declare within the paper that:
“Ayaka Nanmo, Tatsuto Kageyama and Junji Fukuda are co-founders of TrichoSeeds, a company that provides hair regeneration medicine.”
This confirms the unique YNU announcement about TrichoSeeds from earlier this yr that quite a lot of readers mentioned.
- Also printed in June 2022 (however not but peer-reviewed), the Fukuda and Kageyama workforce authored a paper titled: “Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction.”
While doing analysis for this replace, I found the beneath new April 2022 video printed by Yokohama National University with regard to Dr. Fukuda. This all appears to be like to be the actual deal….though I stated the identical up to now in regards to the Dr. Tsuji/Riken workforce. Also see this earlier 2017 video presentation from Dr. Fukuda.
Update: April 15, 2022
Yokohama University and Dr. Junji Fukuda
I contemplate Dr. Fukuda and his workforce to be among the many 5 most essential gamers on this planet which are engaged on a hair loss treatment. Per final yr’s information (see additional beneath), the Yokohama workforce plans to start out human scientific trials in 2023.
In this newest analysis, the workforce managed to make new hair that was at first solely rising beneath the pores and skin of mice to sprout by way of the pores and skin. They did this through using guide-inserted hair microgels (HMGs). They conclude:
“This approach is a promising strategy to advance hair regenerative medicine.”
Update: April 7, 2021
Interview with Dr. Tatsuto Kageyama
Yesterday, in our Discord chat, “DrPhil” posted a hyperlink to a new April interview with Dr. Tatsuto Kageyama of Yokohama National University. It is price a full learn.
After some fast analysis, I spotted that Dr. Kageyama is a co-author in Dr. Fukuda’s essential 2019 paper titled: “Preparation of hair beads and hair follicle germs for regenerative medicine.”
This newest interview with Dr. Kageyama is extraordinarily insightful and inspiring.
Human Trials to Start in 2023
The most essential information is that human trials will begin in 2023. Moreover, the remedy is not going to be too pricey, and it will likely be protected.
Some key quotes after translation:
“We started basic research using human cells in 2018, aiming to start clinical trials in 2023. And we are working hard together with the members of the laboratory so that we can deliver it to everyone as soon as possible.”
“We also believe that we will be able to resolve cost issues.”
Apparently, they’re satisfied that the price of this remedy might be a lot decrease compared to different regenerative drugs remedies. A pleasant change from Dr. Tsuji’s costly hair loss treatment.
The workforce’s mass tradition expertise doesn’t necessitate costly gear. Moreover, the required quantity of hair follicle primordia could be produced with a single tradition container.
Hair Follicle Primordium Creation
The Yokohama National University workforce’s hair multiplication course of entails creating hair follicle primordia. Epithelial cells and mesenchymal cells combine to type a tissue known as “hair follicle primordium“. This is essentially the seed for hair growth.
The process this team uses entails:
- Extract a few healthy scalp hairs.
- Increase the “epithelial cells” and “mesenchymal cells” that exist in these follicles.
- Thereafter, domesticate a considerable amount of hair follicle primordia.
- Transplant these new cells to balding areas of the donor’s scalp to regenerate the hair.
It might be attainable to provide hundreds of hairs from a number of hairs. The entire course of is taken into account to be protected as a result of autologous nature of the remedy.
Japan and Regenerative Medicine
Best of all, in Japan, scientific trials in regenerative drugs are anticipated to maneuver alongside sooner than within the US or EU. The nation has a quickly ageing society with low delivery charges. Therefore, it’s a world chief in anti-aging associated analysis.
The essential triumvirate of Riken (Tsuji), Shiseido, and Yokohama (Fukuda) are all primarily based in Japan. I’m very hopeful that not less than considered one of these three will lastly achieve bringing a subsequent era hair loss remedy or treatment to the market.