I cowl Stemson Therapeutics (or its founder Dr. Alexey Terskikh, or its CEO Geoff Hamilton) at the least a number of instances a 12 months. This firm represents the main hope for a hair multiplication associated hair loss treatment. Among the highlights:
I now simply replace this complete put up twice a 12 months reasonably than write a separate one every time.
Stemson Therapeutics: 2022 Updates
Update: December 30, 2022 — Stemson’s Director of Histology and Pathology Dr. Allan Dovigi wrote an interesting post on Linkedin that has thus far obtained just one remark. I like his enthusiasm on the velocity of progress in organ regeneration and medication normally. Key quote with slight modifications by me:
“At Stemson Therapeutics we are growing hair follicles for transplantation in our patients with alopecia. We are removing the barriers to the cell’s genetic programs and switching them back on to allow regeneration of the original tissues and anatomy. I can observe all the histology of the regenerated hair follicles, epithelial root sheath around hair shafts, dermal papilla, sebaceous glands and pilar erector muscle. I find it simply amazing. Peering through my microscope has never been more exciting.”
It may be very attention-grabbing that he mentions the essential to hair (however often ignored) arrector pilli muscle. He predicts that people will have the ability to regenerate whole organs going ahead, so organ transplants will develop into out of date. Note that Stemson currently has 25 employees with Linkedin accounts.
Update: November 20, 2022 — VP Meghan Samberg presented on Stemson’s iPSC-derived cell remedy method for hair follicle regeneration on the World Congress for Hair Research in Australia.
Update: October 25, 2022 — Interesting new interview with CEO Geoff Hamilton. Key quote:
“We’re trying to get our first product into clinic, which is an autologous cell therapy-based approach to bioengineering hair follicles. It is probably going to be at least a couple of more years before we feel we’re really ready.”
Update: February 12, 2022 — Joe Tillman and Spencer Kobren have launched three mini-interview movies of Stemson CEO Geoff Hamilton. Parts 2 and three are crucial:
Update: February 1, 2022 — Stemson just hired Dr. Kapil Bharti and Dr. George Murphy to its scientific advisory board. Both appear to be famend scientists on this planet of regenerative medication and stem cell analysis.
Update: January 18, 2022 — Mr. Hamilton is roofed in a brand new MIT Technology article titled: “Going bald? Lab-grown hair cells could be on the way.”
Alexey Terskikh and Geoff Hamilton
Update: December 2021 — Stemson founder Alexey Terskikh simply co-authored an attention-grabbing new paper titled “The rise of induced pluripotent stem cell approach to Hair Restoration.”
“Combined with robotics and automation of the transplantation process, this novel regenerative medicine approach is well poised to make hair restoration a routine procedure affordable for everybody who can benefit from it. At present, it seems that the generation of DP cells through the neural crest intermediate has the lowest barrier to enter the clinical trials in the next few years.”
Note that Dr. Hamilton additionally gave the keynote address on the current Global Hair Loss Summit.
Update: October 12, 2021 — Presentation on the Alliance for Regenerative Medicine’s “Meeting on the Mesa”:
Update: September 1, 2021 — Market Knowledge podcast interview with Geoff Hamilton. Make positive to observe the video in there.
Update: July 15, 2021 — Stemson lined on the information by native San Diego ABC News affiliate:
Update: October 2020 — The ISHRS interviewed Dr. Alexey Terskikh on video.
Update: September 2020 — Stemson simply got another $7.5 million in funding from Allergan and Fortunis Capital. h/t reader “James”. Quote from the CEO of Fortunis:
“Stemson’s novel cell therapy approach to treat hair loss has game-changing potential.”
CEO Geoff Hamilton stated the next:
“Stemson has established the biological and technical building blocks which are needed to solve the problem of hair loss. A truly curative solution is now feasible.”
We have heard comparable reward from various different firm CEOs throughout the previous decade. So no use in getting hopes raised this early within the course of.
Note that Allergan is concerned within the hair loss world by way of investments in a big variety of upcoming corporations and applied sciences.
September 14, 2020
Stemson Therapeutics Patent Approved
Earlier at the moment, Stemson Therapeutics introduced that its cornerstone patent had received approval in the US.
This patent (No. 10716808) is titled “Methods and compositions to modulate hair growth”. The expertise is licensed solely from the Sanford Burnham Prebys Medical Discovery Institute.
The course of outlined on this patent entails a novel course of to distinguish Induced Pluripotent Stem Cells (iPSC) into dermal papilla cells (DPCs). The latter cells management hair follicle era and hair biking.
Considering that Stemson is but to even begin human scientific trials, I don’t count on this product to come back to market any time quickly. However, the scientific analysis behind this firm’s expertise appears to be strong, and the corporate itself is nicely funded (see additional under).
On the corporate’s information web page, final week they introduced the hiring of Dr. Meghan Samberg as Vice President of R&D and Preclinical Development.
June 27, 2019
During the final 30 days, we’ve got obtained constructive updates from: Aclaris Therapeutics; Dr. Lowry (new firm Pelage Pharmaceuticals); Follica; Polichem; and Shiseido.
We additionally had a constructive story from Columbia University (Dr. Angela Christiano) this week that I didn’t cowl. It pertain to previous analysis on JAK-STAT signaling and hair regrowth. I didn’t suppose that we might have a extra inspiring month than we’ve got simply had on this planet of hair loss treatment analysis.
Stemson Therapeutics has Arrived
Perhaps the most important story of the 12 months is the truth that Stemson Therapeutics is now a actuality, and so they have officially launched their website. I initially lined this firm in 2018, and mentioned its analysis all the best way again in 2015.
Moreover, Stemson has secured a multi-million dollar investment from pharmaceutical big Allergan. In Dr. Alexey Terskikh’s interview with me in 2017, he talked about that the most important factor holding them again was lack of ample funding.
I’ve requested Dr. Terskikh to present us one other interview quickly and hopefully he’ll settle for. Earlier this month, he instructed me that his lab was given a podium presentation on the ISSCR convention on June twenty seventh. However, he didn’t point out the under shocking improvement.
Functional Hair Follicles Grown from Stem Cells
Earlier at the moment, San Diego primarily based Sanford Burnham Prebys printed a what appears to be groundbreaking new article: Functional Hair Follicle Grown from Stem Cells. Note that this analysis institute is affiliated with Dr. Terskikh. More on their Twitter account.
The breakthrough is as a result of scientists from Sanford Burnham have created natural-looking hair that grows via the pores and skin utilizing human induced pluripotent stem cells (iPSCs). According to the article, this “could revolutionize the hair growth industry”.
Unlike in previous experiments the place new hair progress was beneath the pores and skin, haphazard, and disorderly, the present outcomes produced hair rising above the pores and skin in a uniform sample. The breakthrough was achieved by utilizing a biodegradable 3D scaffold that guided hair progress via the pores and skin in its most popular path.
Actual paper is here. Lead researcher is a Dr. Antonella Pinto.
The present protocol is predicated on mouse epithelial cells mixed with human dermal papilla cells. However, the derivation of the epithelial a part of a hair follicle from human iPSCs is at present underway within the Terskikh lab. Key quote from the article from at the moment:
“Combined human iPSC-derived epithelial and dermal papilla cells will enable the generation of entirely human hair follicles, ready for allogenic transplantation in humans.”
Make positive to examine the difference between autologous and allogenic. Stemson Therapeutics has licensed the above expertise from Sanford Burnham.