Last month, an attention-grabbing new examine was published in PNAS that was titled “MicroRNA-205 (miR-205) promotes hair regeneration by modulating mechanical properties of hair follicle stem cells”.

It looks as if hair follicles turn out to be stiff with age, similar to the remainder of your physique. MicroRNA (miRNA) can reverse the stiffness and regrow hair, no less than in mice. Make certain to additionally learn my previous detailed put up on MicroRNA and hair development.

Softening Stiff Hair Follicles with MicroRNA.
Softening stiff hair follicle stem cells with microRNA (miR-205) regrows hair. Source: PNAS.

Softening Stiff Hair Follicle Stem Cells Regrows Hair

This newest examine was led by scientists from Northwestern University School of Medicine (US), with vital contribution from Singapore’s A*Star) too. Neuroscience News has a succinct abstract on the findings (h/t “curious”). In essence:

  1. Hair follicle stem cells turn out to be stiff and hardened with age, thus hindering hair development.
  2. Northwestern scientists have found a approach to soften these stem cells by growing the manufacturing of miR-205. This in flip promotes hair regrowth in mice.
  3. Future experiments will examine if people see related hair development outcomes after the topical software of miR-205 on scalp hair. The supply shall be finished my nanoparticles.

MicroRNA-205 Promotes Hair Regeneration

When the researchers genetically manipulated hair stem cells to supply extra of a “tiny RNA” termed miR-205, it promoted hair regrowth in each younger and previous mice. It did this by way of gentle and reversible downregulation of many genes, which in flip promoted cell cycle reentry and hair regeneration.

Moreover, per a quote from the corresponding writer Rui Yi:

“These are not new stem cells being generated. We are stimulating the existing stem cells to grow hair. A lot of times we still have stem cells, but they may not be able to generate the hair.”

Interestingly, when folks’s arteries get stiff with age, they get hypertension. Anti-hypertensive drugs (comparable to oral Minoxidil) allow the relief of blood vessels. Topical Minoxidil additionally causes vasodilation (i.e., the widening of blood vessels).


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