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Sirnagen CosmeRNA for Hair Loss: Releasing in 2023 | Hair Loss Cure 2020

Now we actually have a purpose to do away with Kim Jong-un. South Korea simply retains on including groundbreaking firms engaged on hair loss therapies. See my web page on hair loss analysis all over the world for among the most important names. My newest three weblog posts all cowl new groundbreaking work from South Korea. Truly outstanding and fully unintentional.

CosmeRNA from Sirnagen Releasing in 2023

This publish covers a brand new topical hair loss product known as CosmeRNA, whose website is now live. It is made by siRNAgen (South Korea), a subsidiary of Bioneer (South Korea). I briefly lined this firm up to now, however now it deserves its personal publish.

The purpose I’m scripting this publish is because of an awesome new interview with siRNAgen CEO Dr. June Park. Both these new developments had been despatched to me by a reader who needs to stay nameless. Key quote from Dr. Park:

“The first SAMiRNA product will be available for sale in the first half of 2023. We had an unconventional route to commercialization by developing a hair loss cosmeceutical product. CosmeRNA, named after cosmetic RNA, provided an early validation of our platform’s potential as a topical cosmetic product for androgenetic alopecia (hair loss).”

They wil not have to conduct scientific trials since it is a beauty product! The precise launch date is more likely to be in early 2023 per one other quote in the identical interview. After first being finished in South Korea, CosmeRNA’s security research was repeated in Europe by Dermatest in 2022. Note that SAMiRNA is shelf steady in an answer for a yr, so it may be utilized topically.

Ms. Park anticipates the product launch to happen a while in early 2023. They will deal with the European market first because of the area’s extra streamlined cosmeceutical trial and approval course of. It known as Cosmetics Product Notification Portal (CPNP).

Note that I beforehand briefly lined siRNAgen Therapeutics in my publish on OliX Pharmaceuticals. The latter is engaged on a hair loss remedy involving RNA interference (RNAi) through asiRNA (uneven small interfering RNA). The purpose is to scale back androgen receptor (AR) expression on the scalp.

SAMiRNA, Androgen Receptor and Hair Growth

siRNAgen can also be engaged on decreasing AR expression and regrowing hair. However, it’s doing so through remedy with self-assembled micelle inhibitory RNA (SAMiRNA) nanoparticle-type siRNA. See their site for extra on small interfering RNAs (siRNA).

They revealed an important study on this in Nature Journal in January 2022. The encouraging title of this paper is value posting: “Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia.”

The product they use for androgenetic alopecia is a topical known as AR68. It is classed as a beauty ingredient and can be known as Cosmerna-68. In the above talked about paper, they’ve earlier than and after pictures of a affected person that I pasted under. The chart on the appropriate reveals the precise % enchancment with AR68 0.5mg/ml remedy versus placebo. They additionally state the next:

“In the low-dose (0.5 mg/ml) clinical study, AR68 was applied three times per week for 24 weeks, and through quantitative analysis using a phototrichogram, we confirmed increases in total hair counts. In the 24-week long high-dose (5 mg/ml) clinical study, AR68 showed average additional hair growth of 1.3-1.9 hairs/cm2 per month, which is comparable to finasteride. No side effects were observed. Therefore, SAMiRNA targeting AR mRNA is a potential novel topical treatment for AGA.”

Sirnagen CosmeRNA AR68
Sirnagen CosmeRNA SAMiRNA AR68 hair loss remedy. Source: Yun, SI., Lee, SK., Goh, EA. et al. Sci Rep 12, 1607 (2022).

Is this a miracle? Most possible not for many severaly balding folks folks. However, simply as with finasteride, some folks may see stellar outcomes. And for many who are simply beginning to go bald, this could possibly be a a lot wanted non-DHT inhibiting product with few if any uncomfortable side effects.

I’m not a giant believer in cosmetics, however this newest interview with siRNAgen CEO June Park is encouraging. She comes throughout as very clever and honest.

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