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I’ve lined Japanese cosmetics behemoth Shiseido for nearly ten years throughout over a dozen posts. My final put up about them turned too complicated, as I used to be repeatedly appending it with temporary new updates. I used to be awaiting the right time to restart.

Shiseido’s work on a hair loss treatment primarily based on the injection of cultured autologous dermal sheath cup cells (DSCs) is promising and protected. While the corporate has no issues with fundraising, thay have had some points with their partnership with Replicel (Canada). I cannot repeat that story right here, however readers can try my previous posts on these two corporations for extra particulars.

Shiseido’s hair development remedy with the injection of autologous dermal sheath cup cells. Includes work from Replicel.

Shiseido Phase III Study Results Published

Earlier this month, Shiseido released the results of its “Phase III equivalent” research. The precise work was published in “The Journal Of Dermatology” Volume 50, Issue 10, in December 2023. In that very same second hyperlink above, it additionally says “First published: 26 September 2023”, which could imply date of unique Japanese submission.

No-one appears to have seen it on Reddit so far as I can inform. I solely learnt about it resulting from somebody e-mailing me and asking me to examine the top of the primary PubMed hyperlink the place it says: “Grants and funding: Shiseido Group.”

It is no surprise that this growth went by with out discover. For one, the title of the paper doesn’t even point out Shiseido’s identify:

“Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss”.

Even inflicting extra confusion is the truth that they name this a “Phase III equivalent clinical study.” And solely 36 volunteers participated on this trial. Not even remotely near what you count on in a correct large-sized Phase 3 trial. The Shiseido web site’s Hair Regenerative Medicine web page has no new updates both.

In any occasion, that is clearly Shiseido’s trial for its DSC injections. After culturing dermal sheath cup cells (the supply of dermal papilla cells) from the scalp pores and skin of the hair loss affected person, they’re implanted (injected) into the identical affected person’s balding scalp pores and skin to rejuvenate broken hair follicles and promote wholesome hair development.

Among the paper’s many co-authors are the famend Shiseido-affiliated Dr. Ryoji Tsuboi and Dr. Manabu Ohyama. All of the co-authors are additionally related to a minimum of one of many folllowing 4 entities in Japan:

  1. Department of Dermatology, Tokyo Medical University, Tokyo.
  2. Department of Dermatology, Kyorin University Faculty of Medicine, Tokyo.
  3. Department of Dermatology, Toho University Ohashi Medical Center, Tokyo,.
  4. Regenerative Medicine Research & Business. Development Department, Yokohama.

Results

Keeping in thoughts the small measurement of the research, the outcomes whereas optimistic, are a bit underwhelming. Thirty-six female and male contributors with patern hair loss (PHL) have been injected with dermal sheath cup cells. These DSCs have been harvested from non-affected occipital hair follicles twice in quarterly intervals.

On world photographic evaluation, 30% of the contributors confirmed enchancment.

The phototricogram information evaluation confirmed  will increase within the:

  • Cumulative hair diameter of 107.6 ± 152.6 μm/cm>2. This was a +1.4% improve versus baseline.
  • Hair cross-sectional space of 3069.1 ± 10960.7 μm2 /cm2. This was a +3.4% improve versus baseline.
  • Mean hair diameter of 0.9 ± 0.9 μm. This was a +2.2% improve versus baseline.

The feminine and excessive terminal hair ratio teams achieved higher outcomes.

Another complicated assertion:

Of the overall contributors, 62.9% famous a point of enchancment.

It looks like this 62.9% determine was primarily based on affected person suggestions slightly than any type of measurement. And per the maths, this could suggest that 22 of 35 sufferers gave a optimistic response, whereas 1 dropped out of the trials.

I’ve not tried to seek out any lengthy model of this report, as total it leaves a lot to be desired. I hope a a lot lengthier Phase 3 trial continues to be occurring.

And I additionally hope the Shiseido will have the ability to be absolutely clear, despite any pending points with Replicel.

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