In this submit, I cowl two potential hair thickening substances in Stemoxydine and Resveratrol. Quite a lot of readers have talked about each of those through the years. We now even have a product that features each substances (see backside of submit), though no miracle outcomes are anticipated.
When writing my 2017 submit on the Kenogen part of the hair progress cycle, one ingredient that I examine was Stemoxydine. According to a study from 2014, Stemoxydine acts as a kenogen part shortener, resulting in a rise in scalp hair density. Note that males with androgenetic alopecia have longer kenogen phases.
Stemoxydine is a topical hair loss product (not FDA permitted) that was patented in 2012 by the cosmetics behemoth L’Oreal. It is classed as a prolyl-4-hydroxylase (P4H) inhibitor and its chemical construction consists of Diethyl pyridine-2,4-dicarboxylate. According to L’Oreal researchers, P4H inhibition results in the creation of hypoxic (low oxygen) circumstances.
This hypoxia atmosphere is favorable for thicker denser hair progress because of a shorter kenogen part. Stem cells product hair extra successfully underneath the low oxygen circumstances. Besides the sooner talked about 2014 examine from L’Oreal, there isn’t a new proof on the efficacy of Stemoxydine in the direction of hair progress. L’Oreal makes use of Stemoxydine 5% in a couple of of its hair merchandise.
Stemoxydine probably has fewer unwanted effects than Minoxidil primarily based on anecdotal stories and buyer evaluations.
Resveratrol and Hair Growth
Before NAD and NMN dietary supplements together with TA-65 turned fashionable for his or her potential anti-aging results, there was Reservatrol (RSV). The latter “red wine molecule” was initially found in Japan within the Thirties, however turned well-known in 2004 courtesy of Dr. David Sinclair. Over the years, various folks questioned whether or not Resveratrol would profit hair, even simply by making it thicker.
In 2021, a study from China concluded that Resveratrol prolongs the anagen progress part of the hair follicle cycle. It delays development to the catagen transitional part when hair stops rising. Moreover, the researchers discovered hair progress selling results of RSV in mice, human hair follicles and dermal papilla cells. They concluded that RSV is predicted to develop into a possible drug for the prevention and therapy of hair loss.
Serioxyl Denser Hair Treatment
When I initially wrote my finest hair loss shampoos submit, one product that bought talked about in numerous evaluations was L’Oréal’s Serioxyl denser hair scalp resolution. I didn’t assume an excessive amount of of it on the time.
However, extra lately, L’Oreal came out with a new formula version of Serioxyl that incorporates each Stemoxydine 5% and Resveratrol. It presently has a median ranking of 4.3 out of 5 stars on Amazon.
The firm additionally revealed a study on this product in April 2020. They declare that the synergistic impact of utilizing each Resveratrol and Stemoxydine (pyridine-2, 4-dicarboxylic acid diethyl ester) results in denser hair.
In an attention-grabbing 2020 video, hair loss movie star “MattDominance” mentioned making a mixture hair loss product. It incorporates topical finasteride plus topical Stemoxydine (by way of Serioxyl). Also take a look at Australia primarily based “The Hair Loss Show” channel’s 2021 protection of Stemoxydine.