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I initially wrote this submit in 2020. It is now up to date because of the arrival of assorted new hair development merchandise containing all 4 of: Redensyl, Capixyl, Procapil and Baicapil.

Of the lots of of pure hair loss merchandise and peptides, solely a number of dozen are well-known. Among these, there are 4 whose names finish in “yl” or “il” that I’ve heard talked about a number of instances just lately. These 4 are:

  1. Redensyl.
  2. Capixyl.
  3. Procapil.
  4. Baicapil.
  • Redensyl™ is a trademark of Givaudan (Switzerland) that’s produced by subsidiary Induchem.
  • Capixyl™ is a trademark of Lucas Meyer Cosmetics (IFF — US).
  • Procapil™ is a trademark of Sederma (Croda — France).
  • Baicapil™ is a trademark of Provital (Spain).

Update October 29, 2023

New Products with Redensyl, Capixyl, Procapil and Baicapil

Curlsmith's Density Elixir with Redensyl, Procapil, Capixyl, Baicapil and Anagain.
Curlsmith’s full size density elixir with Redensyl, Procapil, Capixyl, Baicapil and Anagain.
  • Yet one other product that incorporates Redensyl, Capixyl, Procapil and Baicapil is Curlsmith’s Full Length Density Elixir (h/t “HZF”). It is a vegan evening serum that additionally incorporates a fifth lively referred to as AnaGain™. These 5 are supplemented by a bunch of pure merchandise resembling Amla, Green Tea and Castor Oil (which will increase PGE2). AnaGain™ is predicated on natural pea sprouts and made by Mibelle Group (Switzerland).
Minimalist hair growth actives with Redensyl, Procapil, Capixyl and Baicapil.
Minimalist hair development serum with Redensyl, Procapil, Capixyl, Baicapil and Anagain.
  • There is a superb new product from Ifra referred to as Minimalist Hair Growth Actives 18%. On Amazon it says it was first launched in August 2021. It is a multi-functional hair development serum with Capixyl 5%, Redensyl 3%, Procapil 3%, Baicapil 4% and Anagain 3%. For a sum complete of 18%. It is non-comedogenic and free from dangerous fragrances and irritants. According to the producer, all these components are instantly obtained from their respective producers.
The Ordinary Multi-Peptide Serum with Redensyl, Procapil, Capixyl and Baicapil.
The Ordinary multi-peptide serum for hair density.
  • There can be a 3rd product that incorporates all 4 peptides. It is made by “The Ordinary” and is known as Multi-Peptide Serum for Hair Density. Note that the components don’t record any of those 4 peptides, however the company website mentions them underneath the “Overview” part. They classify all 4 as “technologies present” within the system. A bit unusual. It additionally incorporates caffeine and numerous plant-based extracts.

Key Benefits

The benefits of every of those key components per Minimalist’s website and different sources are as follows:

  • Capixyl modulates dihydrotestostaerone (DHT) and preserves hair follicle stem cell exercise.
  • Redensyl promotes hair development by revitalizing outer root sheath hair follicle stem cells.
  • Procapil strengthens the hair follicle metabolism and anchoring.
  • Baicapil extends the anagen development part of the hair cycle.
  • Anagain reduces hair loss by stimulating particular sign molecules within the dermal papilla.

I’m skeptical about a few of these claims. However, combining all these components into one product appears very attention-grabbing. Taken individually, I might not count on a lot from any of those peptide based mostly merchandise. Individually, they can’t be as efficient as both of the 2 FDA authorised hair loss medicine available on the market: Finasteride and Minoxidil.

Note {that a} peptide is a brief chain of amino acids. Make positive to learn my detailed submit on amino acids and hair development.

Redensyl, Capixyl and Procapil Combination

It looks like there are a rising variety of compounded merchandise available on the market that embrace a couple of of those 4 components. I record a few of these “combo” merchandise later on this submit. You can get each serums and hair loss shampoos containing these mixture components.

Last month, a reader e-mailed me a hyperlink to a 2019 Turkish research that analyzed a Redensyl plus Capixyl plus Procapil (“RCP”) mixture topical hair loss therapy. The stunning conclusion was that the RCP serum grew more hair in users than topical 5% Minoxidil. One of the earlier than and after photographs with clear new hair development is pasted under.

Note that this “RCP” product is presently reserved by the Turkish Patent Institute underneath the title “Procare”. In the above talked about research, the outline of creating this mixture product appears comparatively easy.

Redensyl, Capixyl and Procapil Hair Growth Treatment
Redensyl, Capixyl, and Procapil Hair Growth Before and After Photo. Source: Karaca N, Akpolat ND (2019). J Cosmo Trichol.

Redensyl

Redensyl Hair Loss Serum.
Redensyl Anti-Hair Loss Serum.

On Amazon, laser hair development machine producer iRestore makes a Redensyl based mostly Anti-Hair Loss Serum. The common ranking presently stands at 3.9 out of 5 stars, based mostly on 450 opinions. However, only a few of these opinions have any earlier than and after photographs.

Redensyl stimulates stem cells and human fibroblasts from the dermal papilla to increase scalp hair growth. While Redensyl is aspect impact free, it’s not formally authorised to deal with hair loss like Finasteride and Minoxidil.

Redensyl is manufactured from a mix of pure botanical components and plant extracts. It additionally incorporates Dihydroquercetin Glucoside (DHQG) and Epigallocatechin Gallate Glucoside (EGCG2). The latter has anti-inflammatory properties through the discount of IL-8 launch by keratinocytes. Redensyl is commonly described as a hair galvanizer that acts on the mobile stage.

Many individuals discover the synergistic results of utilizing Redensyl together with Minoxidil useful to hair development.

Capixyl

Capixyl is a biomimetic sign peptide advanced (acetyl tetrapeptide-3) that’s mixed with a purple clover extract wealthy in Biochanin A. Red clover is called trifolium pratense, which has confirmed hair development and hair density improve advantages. It does this through the inhibition of 5-α-reductase exercise; discount of irritation and cytokines; and stimulation of extracellular matrix (ECM) protein synthesis within the hair follicle neighborhood.

Note that GroMd makes a shampoo and conditioner that features each Redensyl and Capixyl. It additionally incorporates Hairgenyl, which is a peptide-rich yeast extract remoted from azalea flowers. No stories any important capixyl associated negative effects on this product.

Procapil

Vantaggio's Procapil Shampoo & Conditioner
Procapil based mostly Shampoo & Conditioner.

Procapil incorporates three plant-derived substances:

  • Oleanolic acid, which is extracted from olive leaves. It inhibits 5α1 and 5α2 reductase enzymes, thereby lowering dihydrotestosterone (DHT) associated hair loss.
  • Apigenin, a flavonoid extracted from citrus peel. Aids in vasodilation and will increase blood move to the hair roots.
  • Glycinehistidine-lysine peptides, which increase pro-matrix
    metalloproteinase exercise. This in flip advantages the metabolic
    necessities of hair follicles.

One very talked-about product that incorporates each Procapil and Redensyl is Australian made BondiBoost HG shampoo. It is sulfate and paraben free and made for each men and women. It can be vegan and cruelty-free,

Further studying: Reduction of Hair-loss: Matrikines and plant molecules to the rescue.

Baicapil Joins the Club

A lesser recognized however nonetheless standard product is Baicapil. It incorporates a mix of three key botanical components: Scutellaria baicalensis, soy sprouts and wheat sprouts. None of those are thought to trigger any negative effects in people at regular doses.

Scutellaria baicalensis incorporates Baicalin, an essential ingredient in conventional Chinese natural drugs. Baicalin is thought to increase hair growth through rising canonical Wnt/β-catenin signaling and activating dermal papilla cells.

Other Combination Products

More Hair Naturally 9 Stem Cell Therapy for Hair Loss.
More Hair Naturally 9: Stem Cell Therapy for Hair Loss.

— On Amazon, there’s a tremendous costly product referred to as “More Hair Naturally 9: Advanced Stem Cell Therapy For Thinning Hair”. It incorporates medical energy Biacapil, Redensyl and Capixyl. It additionally incorporates mountain ginseng root, bamboo sprouts and stem cells from grownup human fats cells.

— Also out there on Amazon is United Pure’s Hair Growth Support serum and shampoo line. It incorporates Redensyl, Baicapil and Capixyl.

Redenhair Hair Serum
Hair Serum containing Redensyl, Procapil and Capixyl.

— Reader “George” discovered an attention-grabbing hair regenerator serum product from Spain-based Redenhair. It incorporates 3% Redensyl, 3% Procapil and a couple of% Capixyl.

— Reader “Tim” identified that RevivHair Max Hair Stimulating Serum incorporates: Redensyl 5%; Acetyl Tetrapeptide-3, the lively peptide in Capixyl; and Biotinoyl Tripeptide-1, the important thing peptide in Procapil. Moreover, it additionally incorporates Myristoyl Pentapeptide-17 (keratin stimulating peptide), typically used to make eyebrows and eyelashes thicker.

Interestingly, reader “Toccata” posted the under touch upon this weblog in January 2019:

“A few posts ago, John Doe mentioned a company — More Hair Naturally — selling a ferociously expensive, all natural, topical treatment. I noticed it shared a lot of the same ingredients as another topical I bought last year. The difference being I paid $17CAD for 60ml and they are charging $125US! for 50ml.

The topical I bought is: Multi-Peptide Serum for Hair Density.

It was a whimsical purchase that I thought would be for an occasional ‘whatever’ application. But now that I’ve looked closer at the actual studies of the ingredients, I might give this a legitimate daily 12 month trial run. I also microneedle and use Minoxidil so I won’t be able to make a reliable judge on its actual efficacy.”

I assume that Toccata didn’t see any miracle outcomes with this potion, however nonetheless fairly attention-grabbing.

Frequently Asked Questions

Below are some often requested questions on Redensyl, Procapil and Capixyl.

Does Redensyl regrow hair?

Redensyl can regrow as much as 10 p.c of hair per some opinions and research. Moreover, it may possibly improve hair density and thickness considerably. It sends extra hair follicles into the anagen part of the hair development cycle.

What are the components in Redensyl?

Redensyl is manufactured from a mix of pure botanical components and plant extracts. It additionally incorporates Dihydroquercetin Glucoside (DHQG) and Epigallocatechin Gallate Glucoside (EGCG2).

What is Procapil?

Procapil incorporates three plant-derived substances: Oleanolic acid, which is extracted from olive leaves and inhibits the 5α1 and 5α2 reductase enzymes; Apigenin, a flavonoid extracted from citrus peel that aids in vasolidation and will increase blood move to the hair roots; and Glycinehistidine-lysine peptides, which increase pro-matrix metalloproteinase exercise. This in flip advantages the metabolic necessities of hair follicles.

What is Capixyl and does it develop hair?

Capixyl is a biomimetic sign peptide advanced (acetyl tetrapeptide-3) that’s mixed with a purple clover extract wealthy in Biochanin A. Red clover is called trifolium pratense, which has confirmed hair development and hair density improve advantages.

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