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Pelage Pharmaceuticals Logo.

I beforehand wrote about Pelage Pharmaceuticals in my 2019 submit  associated to the analysis of its President and co-founder Dr. William Lowry. The different co-founders are Dr. Heather Christofk and Michael Jung. I additionally coated the findings of Dr. Lowry and Dr. Christofk’s UCLA crew in a 2017 submit.

These UCLA researchers found two topical compounds (RCGD423) and (UK5099) that regrew hair in mice by way of totally different mechanisms. Both medicine contain a rise in lactate manufacturing. This in flip prompts hair follicle stem cells and results in elevated and faster hair progress.

Dr. Lowry’s patent can be found here. Patent and expertise rights to each topical medicine have been completely licensed to Pelage Pharmaceuticals by UCLA.

Pelage Pharmaceuticals Clinical Trial Update

Earlier in the present day, reader “Ben” made an very fascinating discovery on Pelage Pharmaceuticals’ website. The following sentence on the backside:

“Early Phase I clinical data shows statistically significant stem cell activation in the hair follicles after one week of treatment with PP405.”

This is tremendous information. So their trials have began. I ponder if PP405 is RCGD423 or UK5099? Their web site homepage describes PP405 as:

“A novel, non-invasive, topical small molecule drug platform that activates stem cells in the hair follicles directly to stimulate robust hair growth. By targeting an intrinsic metabolic switch in hair follicles, Pelage’s platform is suitable for all genders, skin types, and hair types.”

In different latest information, Pelage appointed Dr. Qing Yu Christina Weng as Chief Medical Officer.

RCGD423

RCGD423 prompts the JAK-STAT signaling pathway, which in flip results in a rise in lactate manufacturing. This additional lactate prompts hair follicle stem cells and ends in faster hair progress.

UK5099

UK5099, blocks pyruvate (a glucose metabolite) from coming into cell mitochondria. This additionally ends in a rise in lactate manufacturing within the hair follicle stem cells, and due to this fact accelerates hair progress.

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