In October 2023, Japanese researchers (led by Junji Fukuda and Tatsuto Kageyama) revealed an attention-grabbing paper that concluded that oxytocin has a positive effect on hair growth through upregulation of dermal papilla cell signature markers. These findings have been later coated by a NHK News video report from Japan.

Oxytocin (OXT) is best referred to as the “love hormone”. It is produced and launched by girls throughout childbirth and lactation. It can be produced throughout pores and skin stimulation, corresponding to when hugging or getting a therapeutic massage. OXT can be referred to as the anti-stress hormone.

In this research, OXT remedy resulted within the upregulation of genes that have been related to hair progress selling components. These included VEGFA (a protein encoded by the VEGF gene), PDGFB, FGF7 and BMP2. This finally leads to peg-like hair sprouting through the improved hair progress means of dermal papilla cells.

Oxytocin and Hair Growth. Source: Nature, 20 October, 2023. Fukuda et al.

Oxytocin, Cinnamic Acid and Hair Growth

I used to be 50/50 about writing a put up on oxytocin and hair progress. We have seen quite a few such previous uncommon examples that finally result in no precise hair loss merchandise.

However, in February 2023, the identical researchers from Japan revealed one more research that discovered cinnamic acid to promote hair growth through the activation of oxytocin receptor (OXTR) expression. Cinnamon is formally referred to as Cinnamomum cassia, and cinnamic acid is a element of Cinnamomum cassia.

“Treatment with cinnamic acid led to upregulation of OXTR and trichogenic gene expression in human dermal papilla (DP) cells.”

Three folks e-mailed me the story about these findings that was published on phy.org a number of weeks in the past. And a number of others additionally posted weblog feedback about this information. No-one appeared to attach each these Japanese research if I recall accurately.

Cinnamic Acid Oxytocin Hair GrowthCinnamic Acid Oxytocin Hair Growth
Cinnamic Acid, Oxytocin Receptor Activation and Hair Growth. Source: Nature, 27 February, 2024. Fukuda et al.

Note that cinnamic acid will also be derived naturally from numerous crops. The most well-known being cinnamon, proven within the picture above. Yet yet one more ingredient so as to add within the record of pure therapies for hair loss.

A 2012 research from Japan discovered that cinnamon extract promotes Type I collagen biosynthesis through the activation of IGF-I signaling in human dermal fibroblasts. Also from 2012, a research from Taiwan concluded that cinnamic aldehyde (a constituent of Cinnamomum cassia) has wonderful anti-inflammatory properties.

A 2018 research from Taiwan discovered that Cinnamomum osmophloeum Kanehira (COK) leaves caused dermal papilla cell proliferation and elevated hair progress in mice.



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