Not Just Obesity: Everyone May Have a ‘Fat Threshold’ for Type 2 Diabetes

By Denise Mann HealthDay Reporter


FRIDAY, Sept. 23, 2022 (HealthDay News) — If you’re one of many thousands and thousands of individuals with type 2 diabetes, shedding pounds may help reverse the blood sugar illness even in the event you aren’t chubby or overweight, new analysis reveals.

Here’s the proof: 70% of individuals with kind 2 diabetes who have been a traditional weight through the research went into remission after they misplaced roughly 10% of their physique weight.

Type 2 diabetes is the type of the illness most carefully tied to weight problems, but round 15% of sufferers aren’t chubby or overweight. They could, nevertheless, be pushing their private “fat threshold.”

“Everyone has a level at which they can no longer store fat safely inside the body — that is determined by genes,” stated research creator Dr. Roy Taylor, a professor of drugs and metabolism at Newcastle University within the United Kingdom.

“If you can’t store more fat under your skin, the fat spills over and starts building up inside the liver,” he defined. When this occurs, an excessive amount of fats goes to the remainder of the physique, together with the pancreas. Insulin-producing cells within the pancreas then cease working accurately, triggering diabetes.

“Type 2 diabetes happens to those who are susceptible, but only when they have become too heavy for their own body,” Taylor famous.

No check can say “you have exceeded your personal fat threshold” but, however some blood markers of stress in fats could at some point show to be a dependable method to measure that threshold, he added.

For the research, 20 folks with diabetes who weren’t chubby or overweight ate 800 energy a day (from low-calorie soups and shakes and non-starchy greens) for 2 to 4 weeks. They did these 3 times, with every cycle adopted by 4 to 6 weeks of weight upkeep.

They misplaced about 10.7% of their weight general, and saved it off for six months to a yr.

Fourteen folks achieved diabetes remission, primarily based on their HbA1c levels. This offers a snapshot of common blood glucose ranges over a number of weeks. Folks in remission not wanted to take diabetes remedy.

This mirrors what’s seen amongst folks with kind 2 diabetes who’re chubby or overweight and shed weight, Taylor stated.

MRI scans confirmed declines of fats contained in the liver and pancreas that have been in step with what’s seen in folks with out diabetes. Specifically, fats within the pancreas fell from a mean of 5.8% to 4.3% amongst folks with diabetes, and the exercise of the insulin-producing cells returned to regular.

It doesn’t take a lot additional fats to thwart the exercise of insulin-producing cells within the pancreas. “You only need an extra half gram of fat in the pancreas to prevent normal insulin production,” Taylor stated.

“Regardless of body mass index [BMI], people diagnosed with type 2 diabetes have more fat inside the body than they can cope with,” he stated. “There is a good chance of remission if they can lose around 10% of their starting weight.”

The research was introduced this week on the European Association for the Study of Diabetes assembly in Stockholm. Findings introduced at medical conferences ought to be thought of preliminary till printed in a peer-reviewed journal.

The relationship between obesity and diabetes is constant and powerful, stated Dr. Scott Kahan, director of the National Center for Weight and Wellness, in Washington, D.C.

“Even exceedingly small amounts of weight gain or excess weight can increase the risk for type 2 diabetes significantly — even in people who are relatively thin,” Kahan noted.

The good news is that small weight losses, often on the order of just a few pounds, can improve blood sugar control and diabetes risk.

“This study further supports the importance of weight management for the prevention and treatment of type 2 diabetes, and strongly suggests that weight management guidance, support and intervention will likely be valuable even in persons with only small amounts of excess weight,” Kahan stated.

SOURCES: Roy Taylor, MD, professor, medicine and metabolism, Newcastle University, Newcastle, U.K.; Scott Kahan, MD, director, National Center for Weight and Wellness, Washington, D.C.; European Association for the Study of Diabetes meeting, Sept. 19-23, 2022

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