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More Evidence for Grey Hair Reversal | Hair Loss Cure 2020

I initially revealed this put up on a remedy for gray hair in January 2016. This is a 3rd complete replace since that point. The  latest updates are listed on prime.

The Latest Updates on Reversing Grey Hair

Update: December 29, 2022 — A new article on anti-aging has a number of gadgets of curiosity in relation to gray hair reversal. A 72-year-old scientist named Gregory Fahy injects sufferers (in addition to himself) with recombinant human development hormone as a way to rejuvenate the thymus gland. This may assist reverse ageing to some extent. Dr. Fahy is described as “having thick dark brown hair and being in enviable shape for a guy of pension age.”

Hair Darkening
Dr. Fahy’s affected person with hair darkening and repigmenting.

One 70-year outdated affected person named Hank Pellissier claims that “his hair, previously white, began growing in brown”. Note that Dr. Fahy’s prescribed routine additionally contains dehydroepiandrosterone (DHEA) and Metformin. More particulars may be discovered on his company website and by way of their clinical trials page. Also of curiosity, Dr. Fahy confirmed a number of of his earlier than and after affected person hair repigmentation images at a Ted Talk in 2020. See after 13:20 mins in this video.

Update: June 22, 2022 — A new gene therapy therapy for a uncommon genetic illness (cystinosis) resulted in main hair darkening as a facet impact. Four of the 5 sufferers have gotten considerably darker hair, and the fifth simply began re-growing his hair put up therapy. Of observe, this gene remedy entails modifying blood cells, and solely modifications the DNA of a small fraction of the affected person’s cells.

Update: May 2022 — An fascinating new video on NMN potentially reversing hair greying and pores and skin ageing. Do observe that each the interviewer and interviewee are concerned within the sale of NMN merchandise. The viewer feedback in there are very fascinating. Make certain to additionally learn my in style put up on NAD and NMN dietary supplements.

Update: May 2022 — Well identified dermatologist Dr. Rodney Sinclair (a giant proponent of oral Minoxidil) stated the next in a new Reddit AMA:

“I have seen hair darkening with minoxidil in my patients.”

Moreover, on Reddit, I’ve learn just a few posts from individuals stating that oral Minoxidil triggered their gray hair to turn out to be darkish once more. In November 2022, one individual even posted that after only one month of two.5 mg/day oral Minoxidil use, his chest and beard hair become dark again. Further under on this put up, I additionally focus on topical Minoxidil inflicting gray hair reversal in some circumstances.

Update: February 2022 — A extremely fascinating examine from China analyzes hair graying regulators each inside and out of doors the hair follicle in inflicting the depletion and dysfunction of melanocyte stem cells (MeSCs). Emerging evidences exhibits that nerves, adipocytes and immune cells exterior of the rapid hair follicle atmosphere  (bulge, bulb and dermal papilla) additionally play essential roles within the regulation of MeSCs.

Update: June 2021 — A brand new experiment mapped human hair greying in relation to recent life stress events. I’m very skeptical about stress inflicting untimely hair greying in most individuals. I’ve devoted an entire part to this in style topic within the second half of this put up.

Update: April 2021 — Harvard University scientists and a group from South Korea are growing a therapy for gray hair using pigment stem cells in hair follicles.

Grey Hair Reversal
50 % of gray hair is re-pigmented after dupilumab therapy. Before and after at 16 weeks. Source: The Journal of Dermatology.

Update: September 2020 — Japanese scientists found an surprising side-effect of dupilumab: reversal of hair graying. Dupilumab is a twin inhibitor of interleukin 4 and interleukin 13. It is used to deal with allergic ailments akin to eczema, bronchial asthma and nasal polyps.

Update: June 2020 — Chinese scientists discovered re-pigmentation of hair in a majority of Alzheimer illness sufferers after extended cholinesterase inhibitor therapy.

Hair Repigmentation
Hair repigmentation after Ustekinumab. Source: Ann Dermatol. 2021 Jun;33(3):300-301.

Update: June 2020 — South Korean researchers introduced the primary case of Ustekinumab-associated hair re-pigmentation. Ustekinumab is a monoclonal antibody remedy that targets interleukin 12 and interleukin 23. It is used to deal with Crohn’s illness, ulcerative colitis, plaque psoriasis and psoriatic arthritis.

Update: January 2020Medication-Induced repigmentation of gray hair evaluation.

“As evidenced by the many cases of gray hair repigmentation in the literature, the development of gray hair may not be an irreversible process. Gray hair is a natural course of aging; however, it may not be an inevitable or permanent process.”

Grey Hair Treatment

Over the previous few years, I’ve collected fairly just a few fascinating hyperlinks associated to a remedy for gray hair. I saved delaying scripting this put up as a result of a everlasting reversal of gray hair is clearly far much less essential than a remedy for hair loss. However, there are some fascinating concepts in reversing graying hair which might be additionally related to reversing hair loss. Both issues additionally appear to have some frequent pathways and genetics.

Moreover, each time we get again a full head of hair, the overwhelming majority of us will little question choose that the brand new hair is pigmented. At that time, gray hair might be deemed to be a big drawback until one prefers the salt and pepper distinguished look.

Finally, for youthful people who find themselves each balding and prematurely graying, it’s a double whammy. Hair loss shampoos and nutritional vitamins and minerals don’t appear to affect hair coloration in most individuals.

Why Does Hair Turn Grey?

An individual’s hair coloration is decided by his or her pigment producing stem cells often known as melanocytes working together with his/her hair follicle stem cells. Hair coloration relies on the presence and ratios of two kinds of melanins: darkish eumelanins (brown and black pigments); and lightweight pheomelanins (pink and yellow pigments). Among the reasons that hair turns gray embody:

  • Genetics.
  • Aging.
  • Hydrogen Peroxide Buildup.
  • Stress.
  • Smoking.

As individuals age, a pure buildup of hydrogen peroxide happens of their hair follicles. This in flip causes oxidative stress, melanocyte destruction and subsequent graying. Side observe: many ladies use hydrogen peroxide options to go blonde.

In 2009, a group of scientists from Germany and the UK figured out why this hydrogen peroxide buildup happens in individuals as they age. They additionally came upon why hydrogen peroxide is in charge for graying hair. Basically, in youthful individuals an enzyme referred to as catalase breaks down hydrogen peroxide into water and oxygen.

However, as individuals grow old, they typically have decrease ranges of this enzyme. They even have decrease ranges of different enzymes (MSR A and B) that restore hydrogen peroxide associated injury to hair follicles. On Amazon, products containing catalase typically have not less than some favorable evaluations concerning the hair darkening facet impact.

The mixture of excessive ranges of hydrogen peroxide and low ranges of MSR A and B disrupts the formation of tyrosinase. That enzyme is essential to melanin manufacturing in hair follicles. Scientists suppose that one thing comparable is at play within the pores and skin situation referred to as vitiligo. One fascinating and strange factor about white nonpigmented hair is that it is thicker and grows faster than pigmented darkish hair.

Our our bodies produce molecules referred to as free radicals that usually react adversely with different molecules. These free radicals could cause quite a lot of injury, however they’re countered by helpful antioxidants. However, it the steadiness between these two lessons of molecules shifts in direction of free radicals, we get damaging oxidative stress. This leads to premature canities, aka the sooner than anticipated whitening of hair.

Anti–interleukin (IL)-17 Therapy Reverses Grey Hair

In May 2018, Italian scientists reported an entire reversal of gray hair in a single 61-year outdated affected person. He first began getting white hair across the age of 45. He was present process interleukin-17 therapy with secukinumab to deal with scalp psoriasis. The under earlier than and after picture after 6 months of therapy is really astounding. The 10-month comply with up confirmed upkeep of outcomes.

Note that this affected person additionally noticed new hair development. The conclusion of the scientists is particularly motivating: “hair whitening and thinning caused by the aging process might be reversible”.

Grey Hair Reversal Anti–Interleukin-17.
Grey hair reversal after anti–Interleukin-17.

Minoxidil may Reverse Grey Hair

In 2017, Dr. Wilma Bergfeld told the New York Times that:

“In early testing of the anti-hair-loss drug minoxidil, she and other researchers noticed the drug sometimes also restored hair color, suggesting it was rejuvenating the melanocytes”.

In 2021, I requested Dr. Bergfeld if there was any additional analysis on the above phenomenon. She responded that she is unaware of something new.

It is stunning that this phenomenon is just not mentioned by many different physicians, since Minoxidil has been in use for many years. Make certain to learn my put up on how Minoxidil works to regrow hair for extra on this essential FDA authorized hair loss drug.

Hair Repigmentation after Immunotherapy

Grey Hair Becomes Dark Again.
Grey hair cured and turns into darkish once more. Source: JAMA Dermatol.

In 2017, scientists had been in a position to reverse gray hair in 13 of 14 sufferers utilizing a brand new immunotherapy based cancer treatment.

The therapy entailed anti–programmed cell dying 1 (anti–PD-1) and anti–programmed cell dying ligand 1 (anti–PD-L1 ).

Hair Repigmentation
Hair repigmentation after most cancers therapy.

The earlier than and after footage of two of the sufferers are extraordinary. I’ve included each on this part.

In latest years, analysis has discovered a connection between immune system involvement in each hair loss and hair untimely greying of the hair.

Stem Cell Factor Protein, Krox20 and Hair Color

In 2017, scientists at UT Southwestern Center within the US led my Dr. Lu Le discovered {that a} protein referred to as stem cell issue (SCF) was important for hair pigmentation. Full examine here. They discovered that the mice with out SCF in Krox20 lineage cells developed gray hair early in life.

Is PC-KUS (a modified pseudocatalase) a False Flag?

In 2013, the identical Germany and UK primarily based group that was mentioned earlier on this put up came out with a potential way to reverse grey hair. According to the article:

The researchers found that this massive build up of hydrogen peroxide can be reversed with a UVB-activated compound called PC-KUS, a modified pseudocatalase. The research team developed this new proprietary treatment.

PC-KUS was also supposed to cure vitiligo. However, according to the UK’s NHS, the research and subsequent publicity on PC-KUS curing grey hair was a bit of a sham.

I am not sure if this avenue of work is definitely over, and perhaps these same scientists will surprise us and come out with better news in the future.

L’Oréal: A Pill to Prevent Grey Hair Forever

During the past decade, France’s cosmetics behemoth L’Oréal has led global research in the private sector when it comes to a search for a cure for grey hair. The company’s head of the “Hair Biology Group”, Mr. Bruno Bernard, is a co-inventor of a topical product to defend and/or regenerate the melanocytes of hair follicles. The patent for this product was filed in 2009.

Moreover, In 2011, L’Oreal announced that it was developing a pill that would prevent grey hair eternally — so long as you continued to take the capsule as soon as a day completely! The medication incorporates an undisclosed fruit extract that mimics the chemical tyrosinase-related protein (TRP-2), an enzyme that protects pigment manufacturing.

Unfortunately, this capsule is not going to trigger current gray hairs to darken, however as a substitute, simply stop new gray hairs from forming. The capsule was alleged to turn out to be out there in 2015, however now we at the moment are effectively previous that yr.

Dr. Mayumi Ito, Wnt Signaling and Hair Pigmentation

Dr. Mayumi Ito is a famend Japanese hair loss analysis scientist who bought her Ph.D from Nagoya University in 2003. She now does analysis and educating at New York University. She has co-authored numerous papers on the affect of Wnt signaling on hair follicle development and regeneration. On this weblog you’ll find many posts that debate this essential subject material.

In 2011, Dr. Ito discovered that Wnt signaling also explains hair losing its pigmentation. Her group even restored hair coloration in mice in 2011 by way of manipulating the Wnt pathway. It stays to be seen when they’ll experiment in people (by way of stem cell injection or gene remedy) and see a profitable reversal of gray hair.

Also in April 2016, scientists (led by Dr. Ito) at NYU Langone Medical Center in New York discovered the molecular pathways responsible for creating the color of skin and hair. They discovered {that a} signaling pathway often known as Edn/EdnrB interacts with other pathways (specifically, the Wnt signaling pathway).

This in flip causes the proliferation of melanocyte stem cells (McSCs) which might be concerned within the earliest phases of pores and skin and hair pigmentation. This means that focusing on Edn/EdnrB signaling in McSCs could be a therapeutic method to advertise hair pigmentation retention.

Is Dr. Cotsarelis additionally Working on Hair Pigmentation?

Interestingly, in December 2011, the famend Dr. George Cotsarelis and Dr. Mayumi Ito co-filed for a patent titled: “Methods for generating new hair follicles, treating baldness, and hair removal.” This patent was approved in December 2015.

In the outline to the patent, it ends with “The present invention also provides methods for hair removal and inducing hair pigmentation.” Quite unimaginable. A 3-in-one answer (hair regrowth, physique hair removing, and gray hair reversal). If solely Dr. Cotsarelis’ predictions and optimism can be realized sooner than he thinks or claims.

Can Finasteride Make Grey Hair Darker?

Over the years, I’ve learn fairly just a few testimonials on hair loss boards the place Finasteride customers have claimed that their hair darkened whereas on Finasteride (which reduces DHT ranges). The majority of those sufferers had very restricted portions of gray hair to start with, so it was arduous for me to inform from their earlier than and after images (when out there) if this phenomenon was true or not. Also see my put up on pure DHT blockers.

However, in 2014, discussion board member “bverotti” who’s a hair transplant clinic consultant in Belgium posted a surprising now deleted earlier than and after picture of one of many clinic’s sufferers on Finasteride. While it exhibits blonde hair turning brown, I consider that as the identical as gray hair turning brown or black. Also, see this hair darkening on finasteride post on Reddit.

I believe that DHT, moreover making many individuals go bald, additionally makes a few of them go gray a lot sooner. I have no idea if this has ever been proven to be true in any form of examine, and I could possibly be unsuitable in my remark.

Using comparable logic as within the above paragraph concerning Finasteride, I believe that the a lot stronger Dutasteride may reverse gray hair. Moreover, just a few of the commentators in my put up on Dutasteride Testimonials point out that the drug darkened their hair.

Could Platelet-Rich Plasma (PRP) Darken Hair?

I’ve lined PRP to deal with hair loss many occasions on this weblog. While the outcomes are by no means assured and PRP is not going to convey again hair in completely bald areas of the scalp, there at the moment are quite a few medical doctors who imagine within the product. I’m skeptical, however prepared to hearken to them.

More related to this weblog put up’s subject material, in November 2015, Dr. Carlos Wesley started an interesting thread on the BTT forums with a photograph displaying PRP and ACell mesotherapy darkening some beforehand clear scalp hair. This was very stunning to me. Moreover, he states that “An additional finding that has also been observed by other practices throughout the world is that PRP can help return some of the original hair color to follicles.” It looks like PRP could possibly be stimulating melanocytes in hair follicles.

Update: A variety of different medical doctors have confirmed this phenomenon of PRP darkening hair coloration in uncommon cases.

Grey Hair Reversal PRP

Stem Cell Transplants to Cure Grey Hair

I’ve mentioned Dr. Takashi Tsuji on this weblog quite a few occasions previously. Several of his outdated movies have proven black pigmented hair rising on a mouse after stem cell transplantation. Moreover, this article on his work has the next sentence in it: “He combined a number of stem cells to adjust the density and color of the hair, raising the possibility of a cure to graying strands.

Will Telomerase Activation Therapy Reverse Grey Hair?

There are a variety of on-line testimonials concerning telomarase remedy by way of the ingestion of the TA-65 complement reversing gray hair and/or rising new hair. There are additionally many opinions on the contrary. I cowl all this and extra in my put up titled “TA-65. telomerase activation and hair regrowth“.

Cancer Treatments that lead to Hair Repigmentation

There have been various reports of people reversing their grey hair while being on drugs to treat cancer. For example:

Natural Remedies and Vitamin Supplements

Natural treatments and remedies for hair loss can sometimes also benefit hair color and pigmentation modestly. However, popular vitamin supplements such as melatonin, B-12, biotin, iron, calcium, zinc, copper, manganese, vitamin D, cysteine and selenium will not change hair color significantly in most people. If a person is severely deficient in any of these important vitamins and minerals, natural remedies can reverse grey hair on rare occasions.

Fo-Ti Root

Several studies as sell as numerous online anecdotal success story reports suggest that Fo-Ti root can darken grey hair. Fo-Ti is also knows as Fallopia multiflora, He Shou Wu and Polygonum multiflorum. Dr. Jerry Cooley told me that some of his patients have  seen grey hair reduction when on a shake product containing Fo-Ti.

Make sure to read reviews and search for user experiences in relation to hair color changes before purchasing Fo-Ti root. Also of note, a new popular supplement pill product called Not Today Grey contains Fo-Ti Root as a key ingredient.

Warning: Please note that excessive consumption of Fo-Ti root can damage your liver. See details in the bottom part of this article.


Calcium Alpha-Ketoglutarate (Ca-AKG) is though to have anti-aging properties. At least in aged mice. Some reviewers of an AKG acid supplement on Amazon (scroll down) mention that their hair darkened while on the product. Dr. Arvind Poswal of India told me that his Ca-AKG product has darkened hair color in multiple people. Also note this study that found α-ketoglutarate (α-KG) stimulated quiescent (telogen) hair follicles to anagen phase hair growth.


Some patients have iodine deficiency, often due to underactive thyroid gland or hormone disorders. Supplementing with iodine can darken grey hair or prevent further graying.

B Vitamins

Vitamin B12, Biotin and other B-complex supplements can help with your hair color in rare instances. However, make sure to get tested first to make sure that you are really deficient in B-12, folate or other B vitamins.

N-Acetyl Cysteine

N-Acetyl Cysteine (NAC) is sometimes touted on sites such as Reddit as benefitting hair color. Not much evidence on this, but its key benefit is proclaimed to come via an increase in glutathione levels.

Iron Deficiency

One of the most common reasons for premature hair loss is iron deficiency. This is especially true for pregnant women, vegans and people on extreme diets. In rare instances, a lack of iron can cause premature grey hair.

Mucuna Puriens

A 1989 report found that treating an 85-year old woman with Mucuna pruriens extract powder for her Parkinson’s disease resulted in drastic darkening of white hair.

Fluoxetine (SSRI)

Antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRIs) have been known to cause hair loss. However, in 2017, a report from Germany discussed how Fluoxetine promoted hair follicle pigmentation. However, the work was done in dissected sample hair from two females and not on actual scalps. Another study from 2020 suggested that Fluoxetine promotes human hair follicle pigmentation via serotonin reuptake inhibition. This could be a new antigreying treatment strategy.

Grey Hair Cure Scams

While not as proliferate as in the hair loss cure industry, the grey hair reversal market is still full of scams. Moreover, while some products have been FDA approved and proven to reverse hair loss in numerous patients, nothing of that sort can be said for products that are touted to reverse grey hair to pigmented hair. Most of these products are natural supplements that will do nothing for your hair color.

In 2015, the US government went after various companies that were making fraudulent claims about their products being able to treat grey hair successfully. Prior to that, in 2013, a nutritional supplement company called “Rise-N-Shine” promised a capsule that may everlasting remedy gray hair. Wonder if that capsule ever got here into shops, and if that’s the case, what number of gullible individuals bought it?

Proctor & Gamble’s ME+ Molecule Hair Dye

Until a remedy for grey hair does come out, individuals must settle for their graying locks, or proceed to make use of hair dyes. In 2013, Proctor & Gamble came out with a supposed permanent hair dye primarily based on a brand new proprietary ME+ molecule. The new molecule (chemical title 2-Methoxymethyl-p-Phenylenediamine) was apparently a results of 20 years of analysis.

Proctor & Gamble’s web site additionally raved about ME+ in early 2014, however it doesn’t seem to be all this early optimism has led to any form of new blockbuster everlasting dye product.

Stress and Plucking is not going to Cause Grey Hair

Most of the articles I’ve learn on this topic appear to point that for the overwhelming majority of individuals, stress is not going to trigger early untimely graying of hair. Plucking hair will certainly not trigger it to go gray. Both of those myths are outdated wives’ tales.

Some articles counsel that US presidents have grayed a lot while in office. However, for my part, these presidents’ mother and father had been additionally often totally gray haired of their outdated age. So it’s not stunning to see extra white hairs showing on presidents’ heads when they’re in workplace of their 50s and 60s. In all chance, it’s gray hair genes relatively than stress that causes middle-age greying.

Update: A brand new 2021 examine discovered that gray hair may probably be reversed by relaxation and taking holidays. Small pattern dimension, restricted outcomes, and solely in these under age 40.

A 2020 examine discovered that hair turned gray and white extra quickly in mice when uncovered to main stress. The results had been via the sympathetic nervous system (struggle or flight response).

Grey Hair is just not Always a Sign of Ageing

Since gray hair often solely impacts individuals of their mid-30s and aftermath (and a full head of white hair is nearly by no means seen in these under the age of fifty), most individuals assume that it’s a signal of ageing. However, this isn’t all the time the case. There isn’t any scarcity of celebrities on TV which have grayed at a really early age.

Perhaps the 2 most well-known examples right here within the US are Anderson Cooper and Jay Leno, who each look very younger for his or her age in that video regardless of graying of their 20s. Cooper started to go grey at just 20 and Leno at 29 in accordance with his assertion in that video. Neither of them appear to have any well being points regardless of now having been gray for many years. If something, each appear to be ageing at slower tempo then the common human.

Hair Color in Men versus in Women

Grey hair is a far better concern for ladies than for males. For the previous, it represents an indication of ageing and an virtually sure finish to careers in appearing and modeling until the hair is dyed on a regular basis. The ladies’s hair dye market is price billion of {dollars} per yr.

For males, this isn’t true, and a few are even purposely shopping for grey hair dye in order to look like George Clooney. The salt and pepper look typically makes males appear distinguished. However, some well-known males such as Mr. Giuliani choose to darken their hair even in outdated age.

Other News and Research on Grey Hair Reversal

Update: Make certain to hearken to this interesting August 2020 podcast on reversing grey hair.

Update: In April 2020, a brand new synthetic melanin nanoparticle coating technique was deemed as a safer, unhazardous and longer lasting option to dye hair.

Update: In March 2020, Eirion Therapeutics had its patent for a gray hair therapy published. It entails utilizing plasminogen activator inhibitor 1 (pai-1) inhibitors to forestall hair graying. Eirion’s pre-clinical product candidates for hair loss and gray hair prevention are ET-02 and ET-03.

Update: In January 2020, scientists from the US and Brazil discovered that excess stress can flip pigmented hair white. Moreover, when cyclin-dependent kinase (CDK) protein was suppressed in mice, their fur didn’t change coloration.

Update: A September 2019 case report from India discovered untimely hair graying reversal after using Melitane 5% lotion and oral hair dietary supplements. Melitane ™ from Redenhair is a biomimetic peptide agonist of an essential melanocyte-stimulating hormone.

Update: In May 2018, researchers from the NIH and the University of Alabama found a connection between hair color and immune system activity. Lead researcher Dr. Melissa Harris runs a lab that researches melanocyte stem cells.

Update: In August 2017, a examine concluded that forced epilation in mice resulted in melanocyte cell and hair coloration regeneration. i.e., a possible gray hair remedy in people.

Update: In June 2017, a really distinctive experiment on one South Korean affected person confirmed important hair darkening. This success was achieved after therapy with a 1,927-nm fractionated Thulium laser and Polydeoxyribonucleotide injections.

Update: In April 2016, a Forbes magazine cover story on Samumed steered that the corporate’s SM04554 hair regrowth product that targets the Wnt pathway may additionally remedy gray hair.

Update: In March 2016, researchers within the UK found key genes for gray hair and extra. The IRF4 gene’s presence appears to correlate with an earlier lack of hair coloration.

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