With oral Minoxidil turning into probably the most mentioned hair loss therapy over the previous 12 months, now is an efficient time to debate the Minoxidil Sulfotransferase (SULT1A1) enzyme.
The under diagram is from a Polish study published in 2022 overlaying Sulfotransferase exercise in hair follicles and the response to Minoxidil therapy. Sulfotransferase 1A1 is encoded by the SULT1A1 gene.
The Minoxidil Sulfotransferase Enzyme
When Minoxidil is used topically on the scalp, it’s transformed into its lively kind (Minoxidil sulfate) by SULT1A1 enzymes, that are positioned within the follicular outer root sheath. However, many individuals’s hair follicles lack excessive ranges of sulfotransferase. So these males (and ladies) are unable to transform even further energy Minoxidil into its lively kind that stimulates hair progress.
Note that Retin-A (Tretinoin) enhances the response to Minoxidil in androgenetic alopecia sufferers by upregulating follicular sulfotransferase enzymes. No marvel so many weblog readers have really useful using each merchandise collectively.
Benefits for Oral Minoxidil too?
When it involves oral Minoxidil, the physique’s liver does the job of changing Minoxidil into Minoxidil sulfate (additionally spelled sulphate). Several articles that I learn appear to recommend that the hair follicle doesn’t have to do the conversion anymore. However, Dr. John Cole stated the next to me:
“If you can’t sulfate it, Minoxidil will not work. Peripherally sulfated Minoxidil cannot enter the cell.”
“Increasing the activity of SULT1A1 can improve the efficacy of topical and low dose oral minoxidil for the treatment of AGA.”
Moreover, the next quote in final 12 months’s essential article from the AAD with reference to LDOM suggests some uncertainty through using the phrase “may”:
“It has been suggested that oral minoxidil may also be converted by liver and platelet sulfotransferase, thereby reaching a higher follicular accumulation.”
It can be fascinating to know if beard progress with topical Minoxidil can be impacted by SULT1A1.
In latest years, there have been some important efforts made to develop merchandise to spice up the Sulfotransferase enzyme with a purpose to enhance the efficacy of Minoxidil. Leading the way in which is Dr. Andy Goren, who began an organization known as Applied Biology that created a Minoxidil Booster product.
However, in June 2021, Applied Biology was acquired by Jupiter Wellness. Luckily, whereas researching for this put up, I got here throughout Jupiter’s hair loss product page. Lo and behold, some fascinating information on their Minoxidil Booster topical product:
- It has been clinically proven to extend the sulfotransferase enzymes wanted for minoxidil to work by as much as 7x over a two-week interval. I assume this 2021 study pertains to these findings. Co-authors embody the well-known hair researchers Dr. Rodney Sinclair and Dr. Rachita Dhurat.
- The product has already been licensed to Taisho, which is Japan’s leading seller of Minoxidil merchandise. They count on to launch the product commercially in 2023.
- Licensed to Cosmofix Technovation and Sanpellegrino Cosmetics, each from India.
Note that within the research that I listed above, 75% of sufferers within the SULT1A1 group demonstrated a optimistic improve in hair progress; in contrast with solely 33% of sufferers within the placebo group. However, the study limitations embody its small pattern and restricted length of observe up.
Update: Right after scripting this put up, I discovered that compounded Minoxidil Sulfate (MXS) primarily based topical formulations can be found for medical use in some elements of the world such as Brazil.