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I beforehand talked about JW Pharmaceutical (South Korea) in my submit on activating the Wnt signaling pathway for hair development. The latter can also be known as the Wnt/β-Catenin pathway.

JW Pharmaceutical’s JW0061 is a first-in-class drug candidate that promotes hair regeneration by activating the Wnt pathway in pores and skin and hair follicle stem cells. However, the corporate is but to start Phase 1 medical trials, so I delayed writing a complete submit on them earlier than.

By far probably the most well-known firm that was working on this space of Wnt activation and hair loss was the a lot hyped Samumed (US). Unfortunately, it folded in 2022 regardless of finishing Phase 3 medical trials.

Also of be aware, one other South Korean firm named CK Regeon (beforehand CK Biotech) is engaged on a a lot anticipated peptide to revive Wnt/beta-catenin signaling and hair development. This peptide is called PTD-DDM or KY19382. It works by inhibition of the interplay between CXXC-type zinc finger protein 5 (CXXC5) and saggy (Dvl).

JW Pharmaceutical Wnt Activator
JW Pharmaceutical Wnt Activator (JW0061) for Hair Growth.

JW Pharmaceutical to Begin Clinical Trials in 2024

Yesterday, a reader despatched me a hyperlink to an replace on JW Pharmaceutical’s patent software for its JW0061 Wnt activator product. Apparently, the corporate has already utilized for patents in over ten nations. They already obtained a patent approved in Russia in March 2023, and have now obtained a patent in Australia.

On JW Pharma’s web site, the product is listed as being in pre-clinical section on the pipeline page. However, on this newest article, there may be an encouraging quote:

“JW Pharmaceutical is currently conducting toxicity evaluation according to Good Laboratory Practice (GLP) at global institutions with the goal of starting clinical trials of JW0061 in the first half of 2024.”

This is affirmation of an estimate JW Pharmaceutical additionally gave final yr. According to an organization consultant, JW0061will complement and replaces present hair loss remedies. JW plans to develop JW0061 as a topical drug.

Note that even way back to 2017, JW Pharma partnered with U Penn and Dr. George Cotsarelis to develop this very therapy (then referred to as CWL080061).

Activating the Wnt Pathway by Binding to the GFRA1 Protein

Note that in November 2022, JW gave a detailed update on their web site regarding the mechanism behind JW0061 and its hair development impact. This was based mostly on a presentation given on the Wnt 2022 convention in Japan. See the enlarged image here.

It demonstrated preclinical efficacy for hair regeneration in mice. According to preclinical knowledge, JW0061 prompts the Wnt signaling pathway by instantly binding to the GFRA1 protein in dermal papilla cells.

Wnt/β-catenin signaling is essential for hair development in any space of the human physique. It is probably the most researched space within the hair loss world. I should have written no less than 50 posts on this weblog through which I no less than briefly point out Wnt. Even wounding (reminiscent of from microneedling or fractional lasers) induced hair development is linked to activation of the Wnt/Beta-Catenin pathway.

Some natural products additionally activate the Wnt/β-Catenin signaling pathway, though their advantages for hair loss are normally weak. Dr. John Cole’s firm used to promote a Wnt Act spray on Amazon, however it’s all the time out of inventory nowadays.

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