An excellent new study from Thailand simply obtained printed on May thirtieth in Frontiers in Cell and Developmental Biology. It examines the present standing and advances in hair regeneration through induced pluripotent stem cells (iPSCs). It additionally compares intimately hair regeneration through this methodology versus through follicular cell sources. I discovered this breakout very fascinating.

I coated Thailand in previous posts concerning docs in that nation pioneering using oral Minoxidil for hair progress (20 plus years in the past). I additionally coated the nation beforehand in relation to male-to-female transsexuals and hair progress. The nation is the world’s chief in relation to MTF transition surgical procedure.

Induced Pluripotent Stem Cells Hair Growth
Human Induced Pluripotent Stem Cells (hiPSCs) and Hair Growth. Source: Front. Cell Dev. Biol., 30 May 2023.

Induced Pluripotent Stem Cells for Hair Regeneration

The two authors of this examine are from the Siriraj Center for Regenerative Medicine and the school of medication at Siriraj Hospital. When it involves hair follicle regeneration from human induced pluripotent stem cells (hiPSCs), the authors break it out into the next classes:

  1. Generation of particular person hair follicle elements. Further damaged out into a) iPSC-derived trichogenic dermal cells. b) iPSC-derived folliculogenic epidermal cells. c) In vitro reconstruction of HFs with iPSC-derived dermal and epidermal cells.
  2. Generation of complete hair follicles from iPSCs. Further damaged out into a) 3D integumentary organ system (IOS). b) Skin organoid.

When it involves the 3D IOS methodology, they provide the instance of Dr. Takashi Tsuji and his RIKEN workforce’s success at producing a bioengineered 3D integumentary organ system (IOS) from mouse iPSCs (miPSCs). They additionally discuss with research by Ohyama and Tsuboi (lead researcher at Shiseido) that I’ve mentioned previously.

They additionally point out Dr. Koehler’s work that I coated in my submit on hair-bearing human pores and skin generated solely from pluripotent stem cells. And after all they point out Stemson Therapeutics co-founder Dr. Terskikh and his previous papers. When I interviewed the latter in 2017, he talked about iPSCs in nice element.

Other topics coated within the paper that I mentioned previously embody biomimetic engineering of human hair and 3D culturing of hair cells.

Hair Follicle Regeneration from Follicular Cell Sources

The authors divide the follicular cell based mostly hair regeneration strategies into the next classes:

  1. Dermal papilla cells. Several a long time in the past, Aderans and Intercytex each noticed some success in hair progress through dermal papilla cell culturing and injection into balding scalps. HairClone is at present attempting one thing comparable. And South Korea’s Epibiotech and Han Bio each appear to be quickly progressing with this expertise.
  2. Dermal sheath cup cells. This is what Shiseido is doing in Japan through the use and enchancment of Replicel (Canada)’s expertise.
  3. Hair follicle stem cells. The primary drawback of this methodology with present culturing strategies is speedy lack of stem cell talents and spontaneous differentiation. Of curiosity, they point out a brand new March 2023 examine from Fukuda et. al in relation to hair follicle stem cell expansion in hair regenerative medication.

Make positive to additionally learn my November 2022 submit on efficient cell remedy for hair regeneration. It was based mostly on a really detailed new analysis paper authored by Epibiotech’s CEO.

Comparison of Cell Based vs hiPSC Based Methods

The under desk from the brand new examine could be very helpful. It compares the benefits and downsides of every methodology of hair regeneration.

The clear hazard of the hiPSC methodology is potential tumorigenesis. Hence the rationale why Stemson Therapeutics and OrganTech must undergo rigorous scientific trials. However, in return, iPSCs have the benefits of limitless beginning materials, limitless enlargement and intrinsic hair-inductive means.

iPSC versus cell based hair regeneration.
Comparison of iPSC versus hair follicle cell based mostly hair regeneration. Source: Front. Cell Dev. Biol., 30 May 2023.


The paper makes the next statements in the direction of the tip which can be of significance:

  • Autologous transplantation of dermal sheath cup cells (DSCs) is beneficial for sufferers with female and male sample hair loss.
  • The technology of DSCs from hiPSCs might present a limiteless supply of cells for transplantation.
  • Nevertheless, bioengineered hair follicles are nonetheless required for some kind of hair loss that contain complete hair follicles. Therefore, producing hair follicles by a biomimetic developmental method is of curiosity.
  • Recent understanding of hair biology and iPSC expertise provides hope for the technology of hair follicle elements and full hair follicles from hiPSCs.
  • Several approaches for reconstructing hair follicles from hiPSCs have been established. However, absolutely useful bioengineered hair follicles have but to be developed.
  • Nevertheless, the authors conclude that these newer methods for de novo folliculogenesis convey us one step nearer to the final word objective.

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