Update: April 19, 2022 — Scientists from Harvard Medical School have managed to regenerate inner ear hair cells that allow listening to (h/t “Rali”). They declare to have moved nearer to a gene remedy resolution for sensorineural listening to loss, though no human scientific trials have began as but.

The analysis workforce was led by Dr. Zheng-Yi Chen. They reported making a drug-like cocktail of various molecules that efficiently regenerated hair cells in a mouse mannequin by reprogramming a sequence of genetic pathways throughout the interior ear. The full research was published on April 17, 2023 in PNAS.

Note that the workforce recognized and used a mixture (cocktail) of drug-like molecules that was composed of small molecules and siRNAs. Make certain to learn my previous associated posts on siRNA in addition to on creating the last word hair loss drug cocktail.

Frequency Therapeutics

Update: April 21, 2023 — Frequency Therapeutics phase IIb clinical trial results for FX-322 have been formally posted. A complete of 142 grownup sufferers have been concerned, 72 of whom obtained the placebo. The remaining 70 obtained a single intratympanic injection of FX-322 (laduviglusib 0.628 mg/sodium valproate 17.72 mg) into their listening to loss affected ear.

In February, the corporate introduced that these trials did not succeed and the corporate’s inventory worth subsequently collapsed.

Update: March 29, 2022 — Update on MIT spinout Frequency Therapeutics and its drug candidate that stimulates interior ear hair cell development.

February 21, 2017

An attention-grabbing new article titled “Drug treatment could combat hearing loss” appears to have little bearing with scalp hair loss. However, listening to loss is normally attributable to everlasting injury to lots of the 15,000 hair cells in every interior ear. Regenerating these with this new drug remedy may additionally point out an analogous potential for regenerating scalp hair cells.

In the article, the writer discusses a new paper that’s printed within the February 21 difficulty of Cell Reports. In truth, the findings of this paper are so vital that the duvet web page of the journal has a photograph taken straight from the analysis. Note that the lead scientists are additionally engaged on this expertise through a brand new firm known as Frequency Therapeutics.

Ear Hair Cell Growth

Ear Hair Follicle Regeneration

In this paper, a workforce of scientists (from MIT, Brigham and Women’s Hospital, and Massachusetts Eye and Ear) have discovered a approach to regenerate tiny interior ear hair follicles through a drug mixture therapy.

This mixture is a two step course of the place in step one, a mixture of medication expands the progenitor cell inhabitants. In the second step, one other mixture of medication induces the brand new cells to distinguish into hair cells.

In one variation of the experiment, the second step was not even necessary because “once the progenitor cells were formed, they were naturally exposed to signals that stimulated them to become mature hair cells”.

I’m fairly sure that I’ve learn articles up to now about ear hair cell regeneration. I’d even have talked about one or two of them in passing on this weblog earlier than. However, this specific article and related research warranted its personal separate publish and caught out for 2 key causes:

  1. The researchers succeeded in regenerating mouse ear hair cells through creating new progenitor cells. This is kind of astounding to me as a result of in common scalp hair loss, scientists have discovered that hair just isn’t misplaced because of the dying of hair cells, however somewhat, due to the death of progenitor cells. So if these scientists can create new progenitor cells within the ear that result in ear hair regeneration, I don’t see how they can’t attempt to use the identical methodology to create new progenitor cells within the scalp.
  2. The researchers achieved their doubtlessly floor breaking achievement through stimulating the Wnt signaling pathway. I’ve mentioned that pathway quite a few occasions on this weblog up to now, because it appears to be essential for scalp hair development. Moreover, well-known firm Samumed’s hair loss drug is concentrating on that very same pathway.

Will ear hair cell analysis and findings change into relevant in the direction of scalp hair cell analysis? I actually hope so, and this new work is encouraging because of the involvement of the Wnt/Beta-Catenin pathway.


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