Fukuda Lab’s hair analysis abstract poster. Source:
Naohiro Uchida, Director of Almo Plastic Clinic Hair Transplantation.

I’ve coated the work of esteemed and prolific Japanese hair loss researcher Dr. Junji Fukuda for nearly ten years. I’ve additionally written the under two detailed posts about his findings. The second of those could be very prolonged as a result of I’ve saved updating it for a number of years.

Make positive to take a look at the Yokohama National University primarily based Fukuda Lab’s hair research page.

A Visit to Fukuda Lab at Yokohama National

Reader “Theo” simply despatched me a hyperlink to a really attention-grabbing diary of a hair transplant surgeon from Japan who simply visited the Fukuda Lab.

Note that whereas Dr. Fukuda relies at Yokohama National University, the analysis appears to be going down at Kanagawa Life Innovation Center (per the above hyperlink). One of the pictures additionally mentions the Kanagawa Center for Clinical Research & Strategy (KCCR). Yokohama is the second largest metropolis in Japan and is the capital of Kanagawa Prefecture. Check out this PDF of the regenerative medicine sector at Kanagawa Prefecture.

From this go to and abstract, I study some very attention-grabbing issues. There are three distinct strategies by which Dr. Fukuda is pursuing hair regeneration. I discussed them in my previous prolonged submit too, however now we have now extra readability.

1) Dermal Papilla Cell Transplantation

“Dermal papilla cell transplantation is about to begin in Japan.

Transplantation of dermal papilla cells (via stratified culture). I assume that the “stratified cuture” within the translation means 3D culturing. Dr. Fukuda mentions that Shiseido already carried out a scientific trial utilizing 2D culturing. In this methodology, cells are are lined up on a flat floor when culturing, nevertheless it solely resulted in a 5% improve in hair quantity. The 3D methodology will doubtless be superior and the scientific trials are about to lastly start! It is hoped to be “put into practical use within five years”.

2) Transplantation of Hair Follicle Primordium

“I think this will take some time.”

The creation of hair follicle primordia means producing hair from scratch. i.e., hair multiplication. I beforehand mentioned the Yokohama workforce’s means of reaching this by way of rising and mixing epithelial cells and mesenchymal cells. These then type “hair follicle primordia“ that are translated to the same donor’s scalp in order to to regenerate hair in thinning regions of the scalp.

Per the latest feedback from Dr. Fukuda, while this process has already been proven by them in mice, human hair is a different animal. Once the primordium tissue is transplanted to human heads, the direction and length grow haphazardly. He thinks that this will take some time.

3) Transplantation of Regenerated Hair Follicles in Vitro (Organoids)

“It will likely take more than 10 years before it can be used in humans.”

The remaining methodology is in vitro regenerated hair follicle transplantation (additionally known as organoid). In this course of, hair follicles are regenerated outdoors the physique, lengthened by nearly 100%, after which transplanted into the scalp. Per Dr. Fukuda, it’ll doubtless take greater than 10 years earlier than it may be utilized in people.

Other Notes

In March 2023, Dr. Fukuda and his Yokohama workforce revealed an necessary hair regeneration associated research. They made an enchancment in the expansion of hair follicle stem cells (HFSCs) and dermal papilla cells by way of the usage of a newly designed microwell array machine.

The Fukuda Lab has even undertaken analysis on electrical stimulation of human dermal papilla cells for hair regeneration.

So in in the future we get two very distinctive insights and forecasts  from Japan! Thanks once more to “Theo” for all of the stellar non-English language updates from Japan and South Korea.





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