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Within the world of 3D bioprinting, essentially the most thrilling developments to stay up for contain the 3D printing of important human physique components. However, for us hair loss victims, 3D bioprinted hair is of foremost curiosity.

Note that there are numerous 3D printing applied sciences with completely different functions. These embrace: 3D printing of scaffolds to help in 3D culturing of hair and dermal papilla cells; laser-assisted bio-printing of hair follicles (that will then be transplanted); and 3D printing of hair programs. The first of those is our major focus.

November 16, 2023

3D Bioprinting of Hair Follicles inside Skin

3D Bioprinting of Hair Follicles inside Skin. Source: Science Advances.

A staff of scientists from Rensselaer Polytechnic Institute (US) has 3D-printed hair follicles in human pores and skin tissue cultured within the lab. The analysis was published in Scientific Advances in October 2023 and led by Dr. Pankaj Karande.

December 21, 2022

New Studies on 3D Bioprinting of Hair Follicles

I’m updating this publish resulting from a number of new research on 3D bioprinting of hair follicles.

  • A brand new December 2022 paper from China concludes {that a} new bead-jet enabled printing of mesenchymal stem cell laden Matrigel beads ends in hair follicle regeneration. Matrigel (much like extracellular matrix) was chosen because the biomaterial for this analysis. Compared with standard 3D in-situ printing methods, bead-jet printing is specialised for stem cell remedy, with improved retention charges. The new know-how may discover a various vary of makes use of in scientific functions for regenerative medication.
  • A November 2022 paper from China discusses an interesting mechanical engineering approach of “in situ” bioprinting. The scientists printed bioinks straight into faulty websites with the intention to promote tissue restore. Epidermal stem cells (Epi-SCs), skin-derived precursors (SKPs), and Matrigel had been “printed” into the injuries of nude mice to advertise hair follicle regeneration. The outcomes confirmed profitable regeneration of hair follicles and different pores and skin appendages at 4 weeks after in situ bioprinting. Moreover, the bioprinting solely barely decreased stem cell viability. These findings help a mechanical engineering methodology for hair follicle regeneration.
  • A June 2022 examine from Japan proposes an approach for the scalable and automatic preparation of extremely hair-inductive grafts utilizing a bioprinter. Mesenchymal–epithelial interactions resulted in environment friendly hair follicle regeneration in mice. However, the brand new hair shafts remained principally beneath the pores and skin. The scientists then developed a singular methodology to allow the hair to sprout upwards by means of the pores and skin. Note that the lead creator of this examine is Junji Fukuda, who I’ve lined many instances on this weblog.
  • A examine from China that was printed in September 2021 discusses a new approach in three-dimensional bioprinting for the tissue engineering of hair follicle reconstruction. This methodology entails a 3D bioprinting approach primarily based on a gelatin/alginate hydrogel to assemble a multilayer composite scaffold. The finish outcomes is an appropriate 3D microenvironment for dermal papilla cells to induce new hair follicle formation. Update: A March 2022 abstract can be read on ScienceDirect.
  • A June 2021 abstract from China is a should learn. It is titled “3D bioprinting for skin tissue engineering: Current status and perspectives.” It covers intimately the newest standing of the primary 3D bioprinting applied sciences (droplet-based, laser-assisted, extrusion-based and stereolithography). It then covers intimately pores and skin bioprinting, hair bioprinting and sweat gland bioprinting. The final talked about shouldn’t be at all times fascinating, therefore the necessity for clinical strength antiperspirants.
  • Another far more detailed study from China that was printed in May 2021 is titled: “Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles.” The researchers managed to concurrently induce sweat gland and hair follicle regeneration. Moreover, they found a symbiotic relationship between sweat gland scaffolds and hair follicle spheroids.
3D Bioprinting of Hair and Sweat Glands.
Using 3D bioprinting and spheroid tradition to create pores and skin with sweat glands and hair follicles. Source: Burns & Trauma, Volume 9, 2021.

Also be certain that to learn my previous tissue engineering of hair follicles publish overlaying work from Dr. Angela Christiano’s staff at Columbia University. It can be summarized within the under 2019 video:

Poietis, L’Oréal, BASF and Dr. Atala

The most enjoyable work on this space of 3D printed hair (and pores and skin) entails the partnership between Poietis, L’Oréal and BASF. Even after years of studying about 3D bioprinting and watching many movies on the topic, it nonetheless looks like science fiction to me. However, that is undoubtedly not fiction, and the essential know-how has already existed and been utilized in folks for over a decade.

Dr. Anthony Atala (a pioneer who I’ve talked about just a few instances on this weblog) has two extremely popular TED Talk movies on this topic from 2010 and 2011. At the time, Dr. Atala’s work was additionally effectively lined in this article. More not too long ago, Dr. Atala has been working with NASA to print synthetic organs in area.

3D Printed Hair and Hair Systems

While we’re most keen on mobile degree 3D hair follicle bioprinting and transplantation, there additionally exist different makes use of of 3D printers that contain hair. Methods that make use of artificial supplies and don’t entail any type of difficult scaffolds and culturing.

MIT Media Group’s Cillia: 3D Printed Hair

The first of those was not extensively lined, however because it entails researchers from MIT, I give it priority. These scientists are a part of the MIT Tangible Media Group, led by Dr. Hiroshi Ishii, and their project is called Cillia. Note that they don’t focus on the human scalp in anyway, and they’re utilizing bitmap technology to print this hair somewhat than any type of precise cells.

The futurism web site has a much more detailed article on the subject. Make positive to additionally see the work from Carnegie Mellon University for creating lifelike hair fibers utilizing a fused deposition modeling (FDM) printer.

CRLAB (Cesare Ragazzi): 3D Printed CNC Hair System

Hair programs and prosthesis should not precisely what me take note of after we focus on 3D printed hair. However, Italian firm CRLAB (previously Cesare Ragazzi) has acquired great publicity lately for its CNC 3D printed hair and scalp prosthesis programs.

You can watch a Lab Tour video of the corporate to study extra. Their work was even covered on 3dprint.com in 2016. The firm’s know-how is actually an try at making a significantly better wig/hairpiece/hair system/toupee than something that’s in existence at present. With far cheaper and frequent upkeep necessities. Plus a superior individualized match (scalp mapping). The know-how relies on CNC programs which are being bought around the globe by Cesare Ragazzi.

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